Biomedical Engineering (BMED)

Introduction to major topics in Biomedical Engineering. Time management, study skills and class scheduling necessary for academic success. Overview of university services. Professional pathways and ethics. Review of career opportunities. 1 seminar.

General introduction to bioengineering analysis applied to representative topics in biomechanics, biofluidics, bioinstrumentation, biomaterials, biotechnology, and related areas. Review of technological needs, testing procedures, governmental regulation, quality of life, and ethical issues. 1 seminar.

General introduction to bioengineering design, including examples of engineering analysis and design applied to representative topics in biomechanics, bioinstrumentation, biomaterials, biotechnology, and related areas. A review of technological needs, design methodology, testing procedures, statistical analysis, governmental regulations, evaluation of costs and benefits, quality of life, and ethical issues. 2 lectures, 1 laboratory.

Treatment of the engineering applications of biology. Genetic engineering and the industrial application of microbiology. Systems physiology with engineering applications. Structure and function relationships in biological systems. The impact of life on its environment. Course may be offered in classroom-based or online format. 2 lectures. Crosslisted as BMED/BRAE 213. Fulfills GE B2.

Directed group study of selected topics. The Class Schedule will list topic selected. Total credit limited to 8 units. 1 to 4 lectures.

Laboratory, field, or engineering education research experience. Development of research skills and techniques. Interested students consult with a faculty member prior to enrolling to clarify expectations and deliverables. Total credit limited to 12 units. Credit/No Credit grading only. Course offered online only.

Fundamentals of biomedical engineering analysis. Use and application of tools and analytical methods used by bioengineers. 3 lectures, 1 laboratory.

Design of biomedical devices and systems using various machine elements and components including gears, welded connections, prime movers. Decision modeling based on technical and economic feasibility. 3 lectures, 1 laboratory.

Introduction to electrical engineering concepts for biomedical engineers. Continuation of basic circuit analysis. Steady state AC circuit analysis and phasor concepts. Application of the Laplace Transform to transient circuit analysis. Introduction to digital logic gates, combinational and sequential logic circuits. 4 lectures.

Individual investigation, research, studies, or surveys of selected problems. Total degree credit limited to 4 units. Total credit limited to 6 units.

Identification and evaluation of commercial opportunities in the healthcare industry. Methods necessary for rapid iteration and market validation of early-stage prototypes, with emphasis on issues critical to biomedical products, including intellectual property, FDA submission, funding sources, and business models. 3 lectures, 1 laboratory.

Finite element based solutions to engineering problems with an emphasis on elastostatic problems in structural mechanics. The power and pitfalls associated with the finite element method highlighted through practical modeling assignments. Introduces the use of commercial finite element codes. 3 lectures, 1 laboratory. Crosslisted as BMED/CE/ME 404.

Examination of human motion biomechanics. Experimental and analytical methods in motion analysis based on rigid body dynamics. Protocols for protection of human subjects in research. Hypothesis-driven research in interdisciplinary teams, including written proposal development and written/oral communication of results to a scientific audience. 1 lecture, 3 activities. Crosslisted as BMED/KINE/ME 409.

Introduction to physiological systems, with emphasis on structure and function of major tissues and organs. Application of mechanics to understand the behavior of these tissues and organs at gross and microscopic levels. Bioelastic solids. Rigid body biomechanics. Biofluids, basic mechanical properties of collagen and elastin, bone, cartilage, muscles, blood vessels, and other living tissues. Application of continuum mechanics to hard and soft tissues. Biomechanical engineering design for clinical applications. 3 lectures, 1 laboratory.

Fundamentals of materials science as applied to bioengineering design. Biocompatibility of materials. Materials characterization and design. Natural and synthetic polymeric materials. Wound repair, foreign body response, blood clotting. Transplantation biology, artificial organs, and tissue engineering. Medical devices, government regulations, and ethical issues. 3 lectures, 1 laboratory.

Overview of the path to market for new medical devices, including nonclinical and clinical evaluation and the regulatory process. Course covers bench, in vitro, and in vivo models, GLP studies, clinical trials, Quality Systems, and FDA clearance and approval processes. 4 lectures.

Physiological fluid mechanics, convective mass transfer, and diffusion in tissue. Properties of blood. Exchange of fluids between capillary beds and tissue. Coupled diffusion and convection. Application of mass transfer coefficients. Rates of diffusion in various physiologic media. 3 lectures, 1 laboratory.

Computational methods for anatomical modeling and boundary value problems in the biomechanics of tissues and biomedical devices. Nonlinear biodynamics, heat flow, cardiac impulse propagation, anatomic modeling, and biomechanics. Course may be offered in classroom-based or online format. 1 lecture, 1 laboratory.

Fundamentals of designing micro/nano scale systems employing sensors, actuators and intelligent controls. Explore mechanics, electronics, heat transfer, photonics, fluid mechanics and biometrics at the micrometer and nanometer scale. Discover how scaling impacts design criteria. Investigate the integration of science and engineering and evaluate applications in living systems. Not open to students with credit in MATE 550. 4 lectures.

Fabrication science and technology for creating micro and nano scale devices. Explore basic processes such as oxidation, diffusion, ion implantation, etching, chemical and physical vapor deposition, photolithography. Develop an understanding of the science of each process and how to select the right steps for fabricating electronic, photon and micro-electro-mechanical systems devices. 3 lectures. Crosslisted as BMED 434/EE 423/MATE 430.

Application of basic processes involved in microfabrication: cleanroom protocol, oxidation, diffusion, photolithography etching and sputtering. Explore process development through fabrication of electronic, photonic or microfluidic devices. Each student will be part of a team that will fabricate and test a device. 1 laboratory. Crosslisted as BMED 435/EE 473/MATE 435.

Fundamentals of material's surface analysis techniques for exploring structure and composition of micro/nano scale features and films will be assessed. Students will develop data analytics for deciding which technique to apply for morphological, elemental or chemical composition analysis. 4 lectures.

Analog and digital circuits in bioinstrumentation. Biomedical signals in continuous and discrete systems. Sampling and digital signal processing. Ultrasound, MRI, CT, Bioelectromagnetics. Electrokinetics. Biophysical phenomena, transducers, and electronics as related to the design of biomedical instrumentation. Potentiometric and amperometric signals and amplifiers. Biopotentials, membrane potentials, chemical sensors. Mechanical transducers for displacement, force and pressure. Temperature sensors. Flow sensors. Light-based instrumentation. Electrical safety. 3 lectures, 1 laboratory.

Focus on the principles associated with instrumentation used to detect surface biopotentials. Emphasis on circuit level design and laboratory implementation of systems used to detect ECG, EMG and EEG signals. Development of practical experience with analog electronic instrumentation used in the design and testing process. A system level design project related to surface biopotential detection and recording. 2 lectures, 2 laboratories.

Current and evolving topics in biomedical engineering, including medical and industrial applications. Exploration of contemporary issues in biomedical engineering, including technical and societal implications. The Class Schedule will list topic selected. Total credit limited to 16 units. Course may be offered in classroom-based or online format. 4 lectures.

Engineering design methodology, design process, project planning, decision making, modeling, construction, and testing of an open-ended design project. Preparation of formal engineering reports. Statistical analysis. Governmental regulations. Bioethical issues. 2 lectures, 2 laboratories.

Engineering design methodology, design process, project planning, decision making, modeling, construction, and testing of an open-ended design project. Preparation of formal engineering reports. Statistical analysis. Governmental regulations. Bioethical issues. 2 lectures, 2 laboratories.

Selection and completion of senior thesis under faculty supervision. Projects typical of problems which graduates must solve in their fields of employment. Thesis results presented in a formal report. Minimum commitment of 120 hours.

Physiology for biomedical engineering students, with an emphasis on control mechanisms and engineering principles. Engineering aspects of basic cell functions; biological control systems; muscle; neural; endocrine, and circulatory systems, digestive, respiratory, renal, and reproductive systems; regulation of metabolism, and defense mechanisms. 3 lectures, 1 laboratory.

Directed group study of selected topics for advanced students. Open to undergraduate and graduate students. The Class Schedule will list topic selected. Total credit limited to 8 units. 1 to 4 lectures.

Directed group laboratory study of selected topics for advanced students. Open to undergraduate and graduate students. The Class Schedule will list topic selected. Total credit limited to 8 units. 1 to 4 laboratories.

Work experience in business, industry, government, and other areas of student career interest. Positions are paid and usually require relocation and registration in course for two consecutive quarters. A fully developed formal report and evaluation by work supervisor is required. Credit/No Credit grading only. No major credit allowed; total credit limited to 24 units.

Individual investigation, research, studies or surveys of selected problems. Advanced study planned and completed under the direction of faculty. Open to graduate students who have demonstrated the ability to do independent work. Total credit limited to 8 units.

Bridging the physical gap between biological and digital systems. Physics of chemical, mechanical, electrical, thermal, and optical sensors relevant to biomedical engineering. Evaluation of transducer performance and system design. Includes realization of a transducer system relevant to graduate projects. 3 lectures, 1 laboratory.

Exploration of areas including cell source and isolation, scaffold selection and modification, tissue cultivation and bioreactor design, and patient implantation. Applications of tissue engineering for creating skin, cartilage, blood vessels, and other tissues. 3 lectures, 1 laboratory.

Examination of the advances in nanotechnology, micro-electro-mechanical systems, materials and clinical technology. Relationship between modern medical achievements and advances in engineering and science, the biomedical engineering industry, and the use of technology in a human context. 4 lectures.

Fundamental principles and applications of biomedical imaging, modalities in medicine. Topics focus on optical imaging techniques, such as brightfield, fluorescence, confocal, multiphoton, DIC, OCT, SEM, and other advanced microscopy techniques. 2 lectures, 2 laboratories.

Analytic and computational representation of biomedical systems with applications in physiology and medicine. Emphasis on biomedical engineering systems, applications, and system modeling including the use of modern tools. Serves as a foundation for biomedical engineering graduate electives and research projects. 4 lectures.

Overview of the mechanical properties of various tissues in the musculoskeletal system, the relationship of these properties to anatomic and histologic structures, and the changes in these properties caused by aging, disease, overuse, and disuse. Tissues covered include bone, cartilage and synovial fluid, ligament, and tendon. 4 lectures.

Structure-function relationships for materials in contact with biological systems. Interactions of materials implanted in the body. Histological and hematological considerations including foreign body responses, inflammation, carcinogenicity, thrombosis, hemolysis, immunogenic and toxic properties. Microbial interaction with material surfaces, degradation. Course may be offered in classroom-based or online format. 4 lectures. Crosslisted as BMED/MATE 530.

Physicochemical hydrodynamics and microfluidic bioseparations, which includes electrokinetics, colloid science and suspension mechanics in the context of Clinical Diagnostic Systems. Understanding key separation design parameters through a course project, theoretical and numerical models. 4 lectures.

Topic groups include microvessel wall structure, network architecture, flow regulation, transport, inflammation, angiogenesis, arteriogenesis, and rarefaction. Additional focus on patho-physiology and the engineering approaches to assess and treat microvascular dysfunction. Not open to students with credit in BMED 540. 3 lectures.

Laboratory procedures include direct visualization of microvessels by microscopy and indirect assessment by skin temperature, evaluation of microvascular networks by casting and immunostaining, and assessment of vascular wall structure by histology. 1 laboratory.

Current topics in biomedical engineering, including medical and industrial applications. Exploration of detailed technical treatment of contemporary issues in biomedical engineering, and examination of technical and societal implications of these subjects. Class Schedule will list topics selected. Total credit limited to 12 units. 4 lectures.

The biophysical basis of the Hodgkin-Huxley active membrane model. A detailed description of the dynamics of voltage gated ion channels. The complete Hodgkin-Huxley active membrane model, with an emphasis on its use in simulating the electrical activity of nerve cells. Equivalent circuit/ circuit simulator based approaches to modeling Hodgkin-Huxley neurons. 4 lectures.

Topics include the etiology, patho-physiology, and rodent models for various forms of disease, such as inflammatory, autoimmune, and monogenic diseases, as well as nucleic acid, protein, and cellular-based therapies for these conditions. Not open to students with credit in BMED 545. 2 lectures.

Procedures include rodent handling, anesthesia, surgically modeling disease, biotherapy delivery, and visualizing/measuring therapeutic efficacy. Additional focus on experimental design, data collection, and analysis. 2 laboratories.

Selected topics of interest to biomedical engineering and other graduate students. Open to graduate students and selected seniors. A forum to share information about research and research tools; an opportunity to discuss topics of interest with professionals in the field, academics, and other graduate students. The Class Schedule will list topic selected. Total credit limited to 4 units. 1 seminar, 1 laboratory.

Directed group study of selected topics for graduate students. Open to undergraduate and graduate students. The Class Schedule will list topic selected. Total credit limited to 8 units. 1 to 4 lectures.

Directed group laboratory study of selected topics for advanced students. Open to undergraduate and graduate students. The Class Schedule will list topic selected. Total credit limited to 8 units. 1 to 4 laboratories.

Independent research experience in biological or biomedical research. Proposal writing and literature review; experimental design, implementation and troubleshooting; oral and poster presentations. 1 seminar and supervised work. Crosslisted as ASCI/BIO/BMED 583. Formerly ASCI/BIO/BMED 594.

Selection and completion of project by individuals or team which is typical of problems graduates must solve in their fields of employment or applied research. Project may involve, but is not limited to, physical modeling and testing of integrated design projects, costs, planning, scheduling and research and may involve students from several disciplines. Formulation of outline, literature, review and project schedule. 2 laboratories.

Continuation of BMED 591. Completion of project by individuals or team which is typical of problems graduates must solve in their fields of employment or applied research. Project may involve, but is not limited to, physical modeling and testing of integrated design projects, costs, planning, scheduling and research. Formulation of outline, literature review, and project schedule. 2 laboratories.

Supervised graduate research and/or development in stem cell science or regenerative medicine and engineering. Provides students with an off-campus industrial or university internship. Total credit limited to 10 units. Crosslisted as ASCI/BIO/BMED 593.

Selection by individual or group, with faculty guidance and approval, of topic for independent research or investigation resulting in a thesis or project to be used to satisfy the degree requirement. An appropriate experimental or analytical thesis or project may be accepted. Total credit limited to 9 units.